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 | Acesso ao texto completo restrito à biblioteca da Embrapa Gado de Leite. Para informações adicionais entre em contato com cnpgl.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Gado de Leite. |
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Data corrente: |
10/12/2021 |
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Data da última atualização: |
10/05/2022 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
ZANETTE, R. de S. S.; FAYER, L.; OLIVEIRA, E. R. de; ALMEIDA, C. G.; OLIVEIRA, C. R. de; OLIVEIRA, L. F. C. de; MARANDUBA, C. M. C.; ALVARENGA, E. C.; BRANDAO, H. de M.; MUNK, M. |
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Afiliação: |
RAFAELLA DE S. S. ZANETTE, Universidade Federal de Juiz de Fora; LEONARA FAYER, Universidade Federal de Juiz de Fora; EDUARDA R. DE OLIVEIRA, Universidade Federal de Juiz de Fora; CAMILA G. ALMEIDA; CAUE RIBEIRO DE OLIVEIRA, CNPDIA; LUIZ F. C. DE OLIVEIRA, Universidade Federal de Juiz de Fora; CARLOS M. C. MARANDUBA, Universidade Federal de Juiz de Fora; ERIKA C. ALVARENGA, Universidade Federal de São João del-Rei; HUMBERTO DE MELLO BRANDAO, CNPGL; MICHELE MUNK, Universidade Federal de Juiz de Fora. |
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Título: |
Cytocompatibility and osteogenic differentiation of stem cells from human exfoliated deciduous teeth with cotton cellulose nanofibers for tissue engineering and regenerative medicine. |
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Ano de publicação: |
2022 |
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Fonte/Imprenta: |
Journal of Biomaterials Science, Polymer Edition, v. 33, n. 5, p. 627-650, 2022. |
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DOI: |
https://doi.org/10.1080/09205063.2021.2008787 |
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Idioma: |
Inglês |
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Notas: |
Publicado online em 24 nov. 2021. |
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Conteúdo: |
Cellulose nanofibers (CNFs) are natural polymers with physical-chemical properties that make them very attractive for modulating stem cell differentiation, a crucial step in tissue engineering and regenerative medicine. Although cellulose is cytocompatible, when materials are in nanoscale, they become more reactive, needing to evaluate its potential toxic effect to ensure safe application. This study aimed to investigate the cytocompatibility of cotton CNF and its differentiation capacity induction on stem cells from human exfoliated deciduous teeth. First, the cotton CNF was characterized. Then, the cytocompatibility and the osteogenic differentiation induced by cotton CNF were examined. The results revealed that cotton CNFs have about 6?18 nm diameters, and the zeta potential was 10 mV. Despite gene expression alteration, the cotton CNF shows good cytocompatibility. The cotton CNF induced an increase in phosphatase alkaline activity and extracellular matrix mineralization. The results indicate that cotton CNF has good cytocompatibility and can promote cell differentiation without using chemical inducers, showing great potential as a new differentiation inductor for tissue engineering and regenerative medicine applications. |
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Palavras-Chave: |
Diferenciação osteogênica; Nanomaterial; Nanotoxicidade; Terapia celular. |
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Thesagro: |
Algodão; Célula; Celulose. |
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Categoria do assunto: |
F Plantas e Produtos de Origem Vegetal |
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Marc: |
LEADER 02382naa a2200337 a 4500
001 2137515
005 2022-05-10
008 2022 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1080/09205063.2021.2008787$2DOI
100 1 $aZANETTE, R. de S. S.
245 $aCytocompatibility and osteogenic differentiation of stem cells from human exfoliated deciduous teeth with cotton cellulose nanofibers for tissue engineering and regenerative medicine.$h[electronic resource]
260 $c2022
500 $aPublicado online em 24 nov. 2021.
520 $aCellulose nanofibers (CNFs) are natural polymers with physical-chemical properties that make them very attractive for modulating stem cell differentiation, a crucial step in tissue engineering and regenerative medicine. Although cellulose is cytocompatible, when materials are in nanoscale, they become more reactive, needing to evaluate its potential toxic effect to ensure safe application. This study aimed to investigate the cytocompatibility of cotton CNF and its differentiation capacity induction on stem cells from human exfoliated deciduous teeth. First, the cotton CNF was characterized. Then, the cytocompatibility and the osteogenic differentiation induced by cotton CNF were examined. The results revealed that cotton CNFs have about 6?18 nm diameters, and the zeta potential was 10 mV. Despite gene expression alteration, the cotton CNF shows good cytocompatibility. The cotton CNF induced an increase in phosphatase alkaline activity and extracellular matrix mineralization. The results indicate that cotton CNF has good cytocompatibility and can promote cell differentiation without using chemical inducers, showing great potential as a new differentiation inductor for tissue engineering and regenerative medicine applications.
650 $aAlgodão
650 $aCélula
650 $aCelulose
653 $aDiferenciação osteogênica
653 $aNanomaterial
653 $aNanotoxicidade
653 $aTerapia celular
700 1 $aFAYER, L.
700 1 $aOLIVEIRA, E. R. de
700 1 $aALMEIDA, C. G.
700 1 $aOLIVEIRA, C. R. de
700 1 $aOLIVEIRA, L. F. C. de
700 1 $aMARANDUBA, C. M. C.
700 1 $aALVARENGA, E. C.
700 1 $aBRANDAO, H. de M.
700 1 $aMUNK, M.
773 $tJournal of Biomaterials Science, Polymer Edition$gv. 33, n. 5, p. 627-650, 2022.
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Registro original: |
Embrapa Gado de Leite (CNPGL) |
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| 1. |  | CARVALHO, L. M. J. de; BIZZO, H. R.; FIGUEIREDO, V. O.; SOUZA, A. M. de; CARDONA, M. D.; FERREIRA, E. E.; AYETA, A. C.; FONSECA, R. B. F.; RANGEL, C. N. Substâncias voláteis na polpa de cagaita (Eugenia dysenterica D.C.) In: CONGRESSO BRASILEIRO DE CIÊNCIA E TECNOLOGIA DE ALIMENTOS, 21.; SEMINÁRIO LATINO AMERICANO E DO CARIBE DE CIÊNCIA E TECNOLOGIA DE ALIMENTOS, 15., 2008, Belo Horizonte. [Trabalhos apresentados]. Campinas: SBCTA, 2008. 1 CD-ROM.| Tipo: Artigo em Anais de Congresso / Nota Técnica |
| Biblioteca(s): Embrapa Agroindústria de Alimentos. |
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| 2. | | CARVALHO, L. M. J. de; MOURA, M. R. L.; MOTTA, E. L. da; CARVALHO, C. W. P.; VIANA, D. S.; CARDONA, M. D.; FERREIRA, E. E.; AYETA, A. C.; MAIUOLO, V.; FONSECA, R. B. F. Caracterização da polpa de cagaita (Eugenia dysenterica D.C.). In: CONGRESSO BRASILEIRO DE CIÊNCIA E TECNOLOGIA DE ALIMENTOS, 21.; SEMINÁRIO LATINO AMERICANO E DO CARIBE DE CIÊNCIA E TECNOLOGIA DE ALIMENTOS, 15., 2008, Belo Horizonte. Ciência e inovação para o desenvolvimento sustentável. Belo Horizonte: SBCTA, 2008. 1 CD-ROM.| Tipo: Artigo em Anais de Congresso / Nota Técnica |
| Biblioteca(s): Embrapa Agroindústria de Alimentos. |
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